Description
Product Characteristics:
Aliases: C C chemokine receptor type 1 antibody, C C CKR 1 antibody, C-C chemokine receptor type 1 antibody, C-C CKR-1 antibody, CC CKR 1 antibody, CC-CKR-1 antibody, CCR 1 antibody, CCR-1 antibody, CCR1 antibody, CCR1_HUMAN antibody, CD 191 antibody, CD191 antibody, CD191 antigen antibody, Chemokine (C C motif) receptor 1 antibody, Chemokine C C motif receptor 1 antibody, CKR 1 antibody, CKR1 antibody, CMKBR 1 antibody, CMKBR1 antibody, CMKR 1 antibody, CMKR1 antibody, HM145 antibody, LD78 receptor antibody, Macrophage inflammatory protein 1 alpha /Rantes receptor antibody, Macrophage inflammatory protein 1 alpha receptor antibody, Macrophage inflammatory protein 1-alpha receptor antibody, Mip 1a R antibody, MIP 1alpha R antibody, MIP-1alpha-R antibody, MIP1aR antibody, RANTES R antibody, RANTES receptor antibody, RANTES-R antibody, SCYAR1 antibody
Target Information: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]